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As opposed to medications prescribed for sedation, the neuroleptics often produce signs of neurological dysfunction, such as extrapyrimidal effects (involuntary movements such as Parkinson-like tremors and other abnormal movements).

The term "antipsychotics" is sometimes used because these drugs are generally used to treat symptoms of paranoia, psychosis, or serious distortions in the perception of reality, such as hallucinations or delusions. The term "minor tranquilizer" (which has been replaced by the more precise terms "sedative-hypnotic" or "anxiolytic") refers to drugs used to treat conditions such as insomnia and anxiety.

However, since their discovery, the use of neuroleptics has fueled an ongoing debate within the mainstream psychiatric community.

This discussion arises primarily as a result of the serious nature and unpredictability of side effects associated with these drugs.

In most developed countries, a large percentage of the people suffering, or in remission, from psychosis are treated in the community.

This community-based treatment depends almost entirely on dosing with neuroleptics.

The most common typical or conventional neuroleptic drugs include: This list ranks the neuroleptics in increasing order of causing sedation and in decreasing order of causing abnormal involuntary muscle movements and potency.

Barbiturates (a class of drugs with more effective sedative-hypnotic effects) replaced bromides in 1903.That is, in order to obtain the same level of intoxication, the tolerant abuser may raise his or her dose to a level that can produce coma and death.The most frequently cited possible cause of mental illnesses is an abnormal hyperactivity of the dopamine neurotransmitter system in the brain.Although the various classes of CNS depressants work in different ways, ultimately it is through their ability to increase GABA activity (thereby decreasing brain activity) that they produce a drowsy or calming effect that is beneficial to those suffering from anxiety or sleep disorders.Although a wide variety of substances can have tranquilizing effects, historically, the term "major tranquilizer" was applied to the category of drugs used to treat severe mental illnesses such as schizophrenia.

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